zaterdag 18 september 2021
Where Did All The People Go?
September 14, 2021 by Michael Snyder
Why are companies all over the world suddenly desperate for workers?
In my entire life I have never seen anything like
this. When the labor shortage started in the United States, a lot of
people blamed overly generous government handouts, but that doesn’t explain why
the exact same thing is happening in nation after nation all over the
globe.
There aren’t enough factory workers, there aren’t enough truck drivers, there aren’t enough port workers, there aren’t enough employees to properly staff our stores, and the shortage of doctors and nurses is becoming a major crisis in some areas. During normal times, we were always told that the global economy was not producing nearly enough jobs for everyone, but now for the very first time we are facing an enormous worldwide labor shortage. It is almost as if millions upon millions of people suddenly disappeared from the system.
Earlier today, I was stunned to learn that a new survey has discovered that 69 percent of global companies are having a hard time finding enough people to hire…
A survey of nearly 45,000 employers across 43 countries showed 69
percent of employers reported difficulty filling roles, a 15-year high,
according to employment-services provider ManpowerGroup Inc. At the same time,
15 countries — focused in Europe and North America — reported their highest
hiring intentions since the survey began in 1962.
Just a few years ago, any company that was willing
to pay decent wages would be absolutely flooded by job applications.
But now everyone can’t stop talking about the “shortage”
of workers.
So where did all the people go?
Normally, global supply chains run as smooth as
butter, but now they are in a complete and utter state of chaos.
And the biggest reason why they are in a complete
and utter state of chaos is because there simply is not enough workers for them
to operate as they usually would.
On a very basic level, we need people to make
stuff, pack stuff, ship stuff, transport stuff, unload stuff and sell stuff.
Every step along the way, shortages of workers are
causing major headaches, and now we are being told that this supply chain
crisis “will last
well into next year”…
A supply chain crunch that was meant to be
temporary now looks like it will last well into next year as the surging delta
variant upends factory production in Asia and disrupts shipping, posing more
shocks to the world economy.
Manufacturers reeling from shortages of key components and higher raw
material and energy costs are being forced into bidding wars to get space on
vessels, pushing freight rates to records and prompting some exporters to raise
prices or simply cancel shipments altogether.
But if we had enough people to do all the jobs that
needed to be done, this crisis could be resolved very rapidly.
So where are they?
As inventories get tighter and tighter, that is
invariably going to drive up prices.
Earlier this week, one of my readers emailed me
about the shortages and price increases that she is seeing in her local
area. I asked her if I could share this with all of you, and she said
that I could…
You can’t find frozen turkeys, frozen hens, frozen cornish hens…the
supply chain HAS indeed been cut. There was 1…just one box of oatmeal on the
shelves of our local food store that are normally stocked through the gills
with food.
Prices are higher…tomato sauce, in a can: what used to cost $0.99 cents
last year now costs $1.50. Chicken drumsticks—we usually throw a bunch in a
crockpot with some bbq sauce and put it over rice for our kids, they love
it….chicken drumsticks, last year were $0.89/pound….now they are $ 1.39 per
pound.
We only buy meat that has been reduced….a rump roast, for instance, was
marked down from $18 dollars to $7….that’s a huge price cut, so we look for
deals like that. But they are hard to find!!! Everything is higher, packaged in
smaller boxes and cups and there is not much of it.
We all knew this was coming….it’s going to get worse, for lots of people
who don’t know what’s happening. We have goats for goat milk and meat if we
need, chickens for eggs and we’ve put back lots of produce we found on sale
over the summer, in the freezer to booster our garden. It’s shocking how much
just is not there…the shelves are empty, moved closer together, and bare spots
are everywhere in grocery stores these days.
Unfortunately, what we have experienced so
far is just the beginning. Global food supplies are going to continue
to get tighter, and that is going to continue to drive up food prices.
Another sector of the economy where the labor
shortage is having a big impact is in the healthcare industry.
Lately, I have been coming across lots of stories
about people dying because they can’t get the care that they need. Just
before I started writing this article, I came across a heartbreaking story
about a 70-year-old woman in Canada that dropped dead after a
six hour wait in a local emergency room…
Bonnie Marie Hall was with her 70-year-old mother —
Susan Tasson — when she died early Wednesday in a Kamloops, B.C., hospital
emergency waiting room after a six-hour wait for care.
Hall says her Ontario-born mother had an infectious
laugh and a “warrior” spirit. She had three sons and two daughters, loved her
grandchildren and had lived in Kamloops since 1987.
“Nobody wants to die in a waiting room. Nobody,” said Hall.
Nobody should ever have to die that way.
But it is going to keep happening, because there is
an acute shortage of healthcare workers right now.
All over the nation, the shortage of nurses has
become a really big deal, and new mandates are just making things even worse…
Hospitals are struggling to comply with the state’s
nurse staffing requirements as pandemic-induced burnout has exacerbated an
already chronic nursing shortage nationwide.
But burnout isn’t the only thing compounding California’s nursing
shortage: The state’s new vaccine mandate for health care workers is already
causing headaches for understaffed hospitals before it is even implemented.
Some traveling nurses — who are in high demand nationwide — are turning down
California assignments because they don’t want to get vaccinated.
There is a serious shortage of doctors as well, and
this is a phenomenon that we are witnessing all over the globe.
For example, over in the UK it is being reported
that there is a “shortfall
of more than 50,000 doctors” right
now…
The NHS may be unable to cope this winter because of a “frightening”
shortfall of more than 50,000 doctors, the head of the British Medical
Association has warned.
Here in the United States, our healthcare system has
never been so close to a state of collapse.
In fact, one doctor recently wrote an article in
which he claimed that it has “already
collapsed”…
As a resident physician who has only trained in an era of COVID—I was
asked to consider graduating from school early in April 2020 to help with
medical staff shortages—my time as a doctor has been defined by working in a
system that has already collapsed. The American health system I work in has
featured limited personal protective equipment, oxygen shortages, and the
construction of field hospitals in convention centers and parking garages. Last
winter, many hospitals across the country instituted crisis standards of care,
forced to ration health services based on criteria that few people envisioned
would be used outside of a mass casualty event, like a terrorist attack. Today,
hospitals are full in much of the country, with patients requiring an ICU being
airlifted thousands of miles in search of a staffed bed. These are not features
of a health system that is approaching failure. These are features of a health
care system that has broken down spectacularly, forcing doctors and patients to
climb through the rubble looking for help.
But just like every other industry, if we had
enough people to do the jobs that needed to be done, we would be fine.
In all the years that I have been writing about the
economy, finding enough workers has never been a problem.
Yet here we are in the middle of 2021, and all of a
sudden there are millions and millions and millions of empty jobs all over the
globe.
Once again, there is a question that I must ask.
Where did all the people go?
This is a question that everyone should be asking,
because the people that are currently running things are not telling you the
truth.
----------------
SECRET
HOLOCAUST: Are millions of vaccine victims disappearing into mass graves?
Mike Adams
body bagsCollapsegenocideHolocaustmass deathmedical violencemurderVaccine Holocaustvaccine warsvaccines
14KVIEWS
(Natural News)
We now have a disturbing new theory emerging that deserves a real
investigation. I credit this to Michael Snyder of The Economic Collapse Blog,
who asked in a recent article, “Where Did All The People Go?”
As
Snyder points out, the global shortage of workers — now widely reported across
the world — can only really be explained if a large number of working-aged
adults are no longer with us. In the United States, with the US Supreme Court
striking down the CDC’s unconstitutional eviction moratorium, people need to work in order
to pay rent (the free rent has stopped). And with covid stimulus payouts having
ended in most states, people can’t support themselves staying at home and not
working… especially with food inflation driving grocery prices through the
roof.
As
Snyder points out:
There
aren’t enough factory workers, there aren’t enough truck drivers, there aren’t
enough port workers, there aren’t enough employees to properly staff our
stores, and the shortage of doctors and nurses is becoming a major crisis in
some areas. During normal times, we were always told that the global
economy was not producing nearly enough jobs for everyone, but now for the very
first time we are facing an enormous worldwide labor shortage. It is
almost as if millions upon millions of people suddenly disappeared from the system.
In
today’s podcast (below), I asked the rest of this question: Is it possible that
hospitals are systematically murdering people and secretly disposing of their
bodies in order to cover up massive covid vaccine deaths?
It’s
no longer unbelievable that hospitals could be engaged in covering up mass
deaths of vaccinated patients
In
any previous year, I would have thought such an idea was a wild conspiracy
theory, but after watching hospital administrators and marketers admit on a recent zoom
video that they were going to alter
covid patient numbers in order to “scare” the public into getting more
vaccines, I now know that hospitals
are murder factories run by anti-human lunatics posing as doctors and
administrators. They have zero interest in helping people or
preventing deaths. Rather, they are now openly working to maximize covid
hospitalization and death numbers among the unvaccinated, and it seems they’ll stop at
nothing to achieve it.
Logically,
they would also do anything to cover up the deaths of vaccinated patients.
Do you have any doubt they would lie and commit health care fraud in order to
hide the truth about vaccine deaths from the public?
A
recent video out of Australia features a local man accusing hospitals of treating vaxxed patients with
ivermectin in order to save their lives, while
simultaneously putting
unvaxxed patients on ventilators in order to murder them
and increase deaths among “unvaccinated.” Watch it here:
Brighteon.com/d39bd385-15c0-470f-9643-4a15b03e3db1
We don’t have proof that the assertions made in this video are 100% true, but I ask you this question: Would it surprise you if they were?
The
answer for most people now is, “No, not at all.”
It’s
now obvious that
many of the doctors, nurses and hospital administrators have zero disregard for
human life and are merely trying to push their covid cult agenda no matter what the cost…
even if it means murdering innocent human beings and chucking their bodies in a
dumpster (or an incinerator) in the hospital parking lot.
Big
Tech silences anyone mentioning covid vaccine injuries or deaths
To
further enforce the cover-up, Big Tech is silencing or even de-platforming
anyone who talks about someone they know being injured or killed by vaccines.
Thus, the channel through which vaccine deaths would normally be shared has
been completely shut down. You are only allowed to say good things about
covid vaccines, not critical things.
So
it’s entirely plausible that millions of Americans could already be dead from
covid vaccines and there would be almost no public mention of it. The media is
completely controlled by Big Pharma, and the tech giants suppress any such
speech. Those are the two ways most people get their information.
Meanwhile,
hospitals and county officials could be easily ordered to fudge the numbers and
cover up all the covid vaccine deaths, in exactly the same way they fudged all
the numbers last year and claimed everybody was dying from covid (while
claiming all the hospital beds were full) while no such thing was happening.
The
one area they don’t fully control is the comments section for published stories
If
this “secret holocaust” were taking place, we should find evidence of it
somewhere, perhaps in corners of the internet that aren’t fully controlled by
Big Pharma and the vaccine enforcers. Comment sections for published stories
might provide precisely such a venue.
What
do we see in the comments for stories about covid vaccines?
As LifeSiteNews recently
reported, “TV station asks for stories of
unvaxxed fatalities but gets deluged with jab death and injury stories.”
While
the ABC News affiliate was trying to push a narrative of unvaccinated people
dying from covid, what they got instead was a now-reported 180,000+ comments from people sharing
stories of vaccine injuries and deaths.
If
nobody was dying from the vaccines, how would this be possible? From the story:
“I
don’t know anyone who died from covid but I do know a 37 year old who got the
vaccine and died of brain aneurysm 8 days later,” wrote a Facebook user under
the name Maximilien Robespierre.
Immediately
below, Richard Smother shared, “My coworkers daughter (12 years old) had to be
rushed to the ER after she collapsed an hour after her second shot.”
Krista
Evans shared, “I know 3 people personally that died shortly after being fully
vaxxed. All the people I know that have had the China virus, had very mild
flu-like symptoms so why the hell would anyone get poked with this poison???”
Becky
Burch commented, “An Aunt died a week after the shot. The family never thought
much about it until visiting with another cousin who had family die after the
shot with the same ‘strange’ issue…not sure of the details. Now, they think it
was the shot.”
Besides
deaths, the testimonies of side effects from the jab cover a wide range of
injuries and symptoms, from heart attacks and blood clots to digestive issues
to loss of sight and movement.
“My
mother had a heart attack 4 days after receiving her first vaccine. She now has
a blood clot in her lung,” Jessica Mauldin commented.
Juli
Smith wrote, “My neighbor died from the vax, the funeral is next week. My mom
can’t feel her arms and legs. My BFF has been in ER several times with
debilitating headaches. My mom and BFF doctors don’t correlate the two but the
timing makes it suspect. My hubby’s doctor refused to let him test for covid
antibodies. These doctors are complicit.”
If
just 1 out of 20 people has already died from a covid vaccines, that would
equate to over 16 million deaths across America
Check
your own circle of family and friends: Aren’t you aware of at least one person
who has died following the covid vaccine?
As
I explain in today’s podcast, if just 1 out of 20 of your friends died
following covid vaccination, that translates into a 5% death rate across the
population, which would be over
16 million deaths in America.
We
aren’t claiming the covid vaccine has killed over 16 million people (yet), but
if nearly nearly everybody knows someone who died from the vaccine, the real
number is almost certainly already in the millions.
It
would be very easy to cover up these deaths, too, if a financial institution
with ties to the government bought
up all the homes previously occupied by now-dead vaccine victims.
Sure enough, this is exactly what BlackRock is doing, as NOQreport writes:
…an
April WSJ article that chronicles BlackRock and other money institutions buying
up single-family homes as quickly as they can at rates higher than the average
homebuyer is willing to pay. They’re buying them up at a premium, and that
should concern everyone whether you’re in the market to buy a home or not.
It
looks like BlackRock
is buying up the excess inventory of homes in order to
keep demand high while so many homeowners are dying and disappearing. A Twitter
thread by @CulturalHusbandry adds:
Blackrock
is buying every single family house they can find, paying 20-50% above asking
price and outbidding normal home buyers. Why are corporations, pension funds
and property investment groups buying entire neighborhoods out from under the
middle class? Lets take a look. Homes are popping up on MLS and going under
contract within a few hours. Blackrock, among others, are buying up thousands
of new homes and entire neighborhoods.
Funeral
director John O’Looney blows the whistle on mass deaths from covid
A
very important interview with John O’Looney from Milton Keynes Family Funeral Services in the UK is spreading like wildfire across the ‘net. It reveals
truly shocking, disturbing information about hospitals mass murdering patients
in the name of “covid,” and shuttling a steady stream of bodies to funeral
services.
Watch
it here:
Brighteon.com/ff7c79ce-367e-478d-aa74-76868f454e4b
And
of course, video platforms across the ‘net have long carried videos
revealing FEMA
coffins stacked in large numbers at various locations
across America. Here’s one such video, via Brighteon.com:
A
similar video about FEMA mass grave sites in Texas is also available
on Bitchute.
It’s
fairly obvious that FEMA is planning for mass deaths, and that this planning
has been under way for many years. Thus, there already exists an infrastructure
to cause millions of dead bodies to vanish into coffins and mass graves, all
under the watchful eye of the US government which is waging biological warfare
against the American people. This isn’t absolute proof that such events are
happening, but it shows they are plausible and
that the infrastructure is already in place.
In
today’s Situation Update podcast, I discuss the growing realization that
millions of people seem to be vanishing from our economy, leaving small
employers high and dry with no one left to fill the now 10+ million job
openings that are necessary to run the businesses that keep America afloat.
Listen
and decide for yourself whether you think covid vaccines are already killing
millions across America while a corrupt, treasonous government is covering it
all up and silencing those who try to speak out. And ask yourself this
important questions: If covid vaccines were perfectly safe and effective, why
would Big Tech have to censor so many people who have witnessed people being
injured or killed by those very same vaccines?
Brighteon.com/87e3c4f5-7e7e-4b96-ad46-37ece66e17e6
Find
more interviews and podcasts each day at:
https://www.brighteon.com/channels/hrreport
300 “vaccin-critici” betogen voor gebouwen VTM en VRT
Zo’n 300 betogers hebben op zaterdagmiddag gedemonstreerd voor de gebouwen van nieuwszenders VTM en VRT. Ze betoogden uit onvrede met het coronabeleid, als protest tegen een mogelijke vaccinatieplicht, maar ook tegen de manier waarop ze in de media aan bod komen.
“We zijn geen antivaxers. We zijn tegen een experimenteel gebruik van vaccins”, speechte één van de organisatoren voor het VTM-gebouw in Antwerpen. Daarna riep hij alle aanwezigen “gevaccineerd of niet” om elkaar te knuffelen. De demonstranten eisen “een open debat” van de nieuwszenders. Ze willen dat er in de media meer aandacht komt voor hun meningen en standpunten.
Na een half uur was de betoging in Antwerpen voorbij.
VRT en VTM
Er worden deze zaterdag in een tiental landen betogingen georganiseerd voor de gebouwen van de lokale mediabedrijven. In België werd er opgeroepen om vandaag onder meer te betogen in Antwerpen, voor de gebouwen van VRT en RTBf aan de Reyerslaan in Brussel, en een lokale afdeling van RTBf in Luik. (cel)
De betogers in Antwerpen verwijten de media dat ze geen aandacht hebben voor hun meningen. — © YouTube
Traitement précoce de la Covid-19 : la colchicine offre un espoir à confirmer
| 26 janv.
2021 | par Caducee.net | | Partager
La colchicine,
un anti-inflammatoire puissant
Extrait des fleurs de colchique, la colchicine est
un alcaloïde puissant qui se présente sous la forme de comprimé à avaler. Ce
médicament est indiqué dans le traitement et la prévention des crises de
goutte, la maladie périodique, la maladie de Behçet et le traitement de la
péricardite aiguë idiopathique. Si ce médicament est délivré uniquement sur
ordonnance, c’est avant tout pour éviter les risques de surdosage, car la marge
entre la dose thérapeutique et la dose toxique est très étroite. Dans le
traitement de la goutte, la posologie est habituellement de 1 à
3 comprimés de 1 mg par jour. La dose toxique est voisine de
10 mg par jour et au-delà de 40 mg jour, la dose serait constamment
mortelle selon les RCP.
Si la colchicine ne doit jamais être administrée
sans avis et prescription médicale, elle présente néanmoins un bon profil de
sécurité et est largement utilisée dans le traitement de la goutte. Elle par
ailleurs relativement bon marché avec une boite de 20 comprimés qui en
France coute moins de 5 €.
En avril 2020, Le Dr Jean-Claude Tardif,
directeur du centre de recherche de l’Institut de Cardiologie de Montréal,
cherche à évaluer l’efficacité de la colchicine comme modulateur de la réponse
inflammatoire et immunitaire des patients COVID-19 qui se traduit souvent par
une libération massive de cytokines particulièrement dévastatrice pour
l’organisme.
Le Dr Tardif, met alors en œuvre l’étude COLCORONA
et cherche à recruter 6000 sujets présentant au moins un facteur de
comorbidité (hypertension, diabète, BPCO/asthme, insuffisance cardiaque,
maladie coronarienne…)
Une étude « sans
contact »
COLCORONA est une étude clinique « sans contact »,
randomisée, à double insu et contrôlée par placébo. Elle a été déployée en
ambulatoire au Canada, aux États-Unis, en Europe, en Amérique du Sud ainsi
qu’en Afrique du Sud. Elle vise à déterminer si la colchicine pouvait réduire
les risques de complications sévères liées à la COVID-19 et notamment la
« tempête inflammatoire » provoquée par « l’orage de cytokines ».
COLCORONA a été menée auprès d’environ
4 500 patients atteints de la COVID-19 n’étant pas hospitalisés au moment
de l’inclusion, avec au moins un facteur de risque de complications de la
COVID-19.
Les patients dont le diagnostic était confirmé par
un test PCR recevaient soit de la colchicine à hauteur de 0,5 mg deux fois
par jour pendant 3 jours et une fois par jour les 27 jours suivants
soit un placebo. Des consultations de suivi étaient ensuite menées à distance
par téléphone ou en vidéo à j 15 et j 30 après le début du traitement.
Pour l’ICM, il s’agit de la plus grande
étude à l’échelle mondiale testant un médicament administré oralement chez les
patients non hospitalisés avec la COVID-19.
Des résultats
prometteurs pour la colchicine dans la Covid-19
Selon le Dr Tardif, les résultats ont démontré que
la colchicine réduisait de 21 % le risque de décès ou d’hospitalisations
chez les patients atteints de la COVID-19 comparativement au groupe placébo. « Ce
résultat obtenu pour l’ensemble des 4 488 patients de l’étude approchait
la signification statistique. L’analyse des 4 159 patients dont le
diagnostic de COVID-19 était prouvé par un test nasopharyngé (PCR) a montré que
la colchicine réduisait de façon statistiquement significative le risque de décès
ou d’hospitalisations comparativement au placébo. Chez ces patients avec
diagnostic prouvé de COVID-19, la colchicine a entraîné des réductions des
hospitalisations de 25 %, du besoin de ventilation mécanique de 50 %,
et des décès de 44 %. Cette découverte scientifique majeure fait de la
colchicine le premier médicament oral au monde qui pourrait traiter les
patients en phase préhospitalière. »
« Notre étude a montré l’efficacité du traitement
utilisant la colchicine pour prévenir le phénomène de “tempête inflammatoire
majeure” et réduire les complications liées à la COVID-19 »
Des données
dont la fiabilité reste à confirmer
Si l’espoir de soulager les systèmes de santé avec
la colchicine comme traitement précoce bon marché est réel, il demeure d’autant
plus mince que l’étude est visiblement incomplète et qu’elle n’a pas encore été
publiée dans une revue scientifique.
Le Pr Mathieu Molimard, chef du service de
pharmacologie médicale au CHU de Bordeaux explique pour LCI « Il ne s’agit
pas d’une étude complète. À la base, elle devait porter sur
6 000 patients. Or, ce n’est pas le cas. C’est un peu comme donner les
résultats d’un tiercé à la mi-course ». Il met également en doute la
fiabilité des données de l’étude qui se contentent d’approcher le seuil de la signification
statistique sans pour autant l’atteindre. « Pour qu’une étude soit
considérée comme fiable, le seuil est fixé à 5 %. Au-delà de ce
pourcentage, on estime que la fiabilité des résultats n’est pas suffisante pour
en tirer des conclusions ».
D’autres médecins, comme Steven E. Nissen
regrette sur Medscape la communication trop vague de l’ICM qui ne
mentionne dans son communiqué de presse ni les rapports de risque, ni
les intervalles de confiance, ni les valeurs P.
La société Française de Pharmacologie
dénombre 27 études dans le monde testant
l’efficacité de la colchicine chez des patients infectés par le Sars-CoV-2,
notamment dans l’étude britannique RECOVERY. Dans un avis mis
à jour le 16 janvier 2021, elle publie « En l’état actuel des
connaissances, l’efficacité de la colchicine dans la prévention ou le
traitement des infections à COVID-19 n’a pas été démontrée. Son utilisation ne
peut donc pas être recommandée au vu des données actuelles pour le traitement
de la COVID-19. Des études de plus grande ampleur et de meilleure qualité
méthodologique sont nécessaires pour démontrer l’efficacité éventuelle de la
colchicine dans la prise en charge de la COVID-19. »
Pour répondre à ses détracteurs, l’ICM
explique que la publication scientifique est en cours de rédaction et sera
soumise dans les prochaines semaines dans une revue à comité de lecture.
Feu vert en
Grèce pour la colchicine dans le traitement ambulatoire de la Covid-19
Si pour certains médecins déjà échaudés par le
débat sans fin sur l’hydroxychloroquine, la communication de l’ICM suscite une
certaine défiance, ce n’est visiblement pas le cas de l’Agence grecque des
médicaments qui a donné lundi 25 janvier son feu vert pour la
prescription de la colchicine dans le cadre de la Covid-19.
Si pour le moment, cette autorisation se limite au
traitement à domicile des patients de plus de 60 ans, elle pourrait
néanmoins être étendue rapidement aux patients covid présentant des facteurs de
comorbidités cardiaques ou respiratoires.
Descripteur MESH : Colchicine , Thérapeutique , Patients , Médecins , Communication , Cardiologie , Risque , Maladie , Goutte , Diagnostic , Pharmacologie , Afrique , France , Sécurité , Canada , Fleurs , Ventilation , Comorbidité , Santé , Europe , Amérique du Sud , Grèce , Téléphone , Lecture , Recherche , Mécanique , Confiance , Intervalles
de confiance , Placebo , Cytokines , Diabète , Hypertension
artérielle , Péricardite , Maladie de
Behçet
Covid-19 : la colchicine réduit le risque
d'hospitalisation et de décès, selon l'étude Colcorona
Volume 90%
Le responsable de l'étude Colcorona, le docteur
Jean-Claude Tardif répond à nos questions sur le traitement par la colchicine
de patients touchés par le Covid-19.
28 JAN 2021
Mise à jour 28.01.2021 à 14:08
par
L’Institut de Cardiologie de Montréal (ICM) a annoncé,
le 22 janvier 2021, que son étude nommée "Colcorona" démontre que la
colchicine est efficace pour traiter les patients non-hospitalisés atteints du
Covid-19. Mais ce médicament à marge thérapeutique étroite est aussi un poison
si la dose n'est pas bien respectée. Explications et entretien avec le docteur
Jean-Claude Tardif, directeur du Centre de recherche de l’ICM.
C'est peut-être une éclaircie dans le ciel
très sombre de la pandémie de coronavirus : un médicament permet de "réduire de façon statistiquement
significative le risque de décès ou d’hospitalisations des personnes touchées
par le Covid-19", selon l'Institut de cardiologie de Montréal (ICM). Ce traitement à base de colchicine, administré
oralement à des personnes positives au coronavirus pourrait devenir "le premier
médicament oral au monde de traitement des patients en phase
pré-hospitalière", toujours selon l'ICM . La colchicine
est un puissant anti-inflammatoire, utilisé depuis très lontemps pour le
traitement de la goutte. Mais la colchocine est aussi un poison : la dose
thérapeutique est proche de la dose toxique, ce qui signifie que sa
concentration dans l'organisme peut être très vite dangereuse avec des effets
indésirables graves pour le patient.
Extrait de l'article
"Ce qu’il faut savoir sur la colchicine", sur le site du Réseau
français des centre régionaux de pharmacovigilance — RFCRPV
La colchicine est un alcaloïde extrait
d’une plante, le colchique et appartient à la famille des « poisons du fuseau ».
Elle agit en diminuant l’inflammation et en
freinant la production d’acide lactique en maintenant le pH local normal. En
effet, l’acidité favorise la précipitation des cristaux d’urate, point de
départ de la crise de goutte. La colchicine agit également en bloquant la division
cellulaire ce qui explique notamment sa toxicité digestive et hématologique, les cellules gastriques et de la moelle osseuse étant à
forte division cellulaire.
La colchicine est un médicament à marge thérapeutique étroite, ce qui signifie que toute variation de sa concentration dans votre organisme,
même légère, peut éventuellement entraîner des effets indésirables,
potentiellement graves. En d’autres
termes, la dose thérapeutique est proche de la dose toxique.
En
France, la colchicine est
disponible :
·
seule dans
la spécialité Colchicine
Opocalcium® (comprimés à 1 mg)
·
en associa
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