vrijdag 17 juni 2022

Vaccine-Induced Tolerance to Spike Protein ...

 


.... Explains "Protection from Severe Disease" and Endless Reinfections

 

     16/06/2022

 

In the last section of my post from yesterday, I asked, why doesn’t Paxlovid work for vaccinated people.

 

Try to stop and think for a minute. Ask yourself a question: why, exactly, is Paxlovid not working in the vaccinated?

The problem is not with Paxlovid, it is the same medication as given to the unvaccinated. The problem is with the immune systems of the vaccinated. The vaccinated cannot clear Covid, while replication is temporarily paused by Paxlovid. The unvaccinated can. Why?

It is a question that I would like to explore, as it may be key to multiple reinfections of the vaccinated, as well as to “less severe disease” that the vaccinated are having, while simultaneously having higher viral loads.

Both phenomena are explained by lack of immune reaction to Sars-Cov-2 from deprogrammed immune systems that were unset and imprinted by several mRNA spike protein transfections.

Part of “severe disease” comes from cytokine storms, caused by an overreaction of immune systems. Well, if immune systems are deprogrammed, they will not overreact — not even react properly — and will not clear the virus either. They will not prevent reinfections, as well.

 

A Twitter user @SimonBuresch, who saw my substack post, provided a link to a very interesting anonymous write-up from Sep 2021. I am quoting it verbatim below, because it is a very interesting thought that explains ALMOST everything we are seeing. It is also notable for WHEN it was posted, which was almost a year ago.

However, before you read the quoted article, I must point out that this anonymous explanation may easily be not quite correct and things must be much worse than “Mark L” is hypothesizing.

Specifically, it may be that mRNA vaccination unsets the entire immunity and makes people more vulnerable to Covid, as well as to non-Covid “vaccinated people illnesses” that they seem to get more easily, such as the notorious “Australian Flu” that makes people bedridden for 10 days. (normally flu clears easily in 3-4 days). I have noticed those “vaccinated people illnesses” in some of my acquaintances. This does not even bring up “monkeypox” or “Crimean Congo” or other exotics. I consider that worse possibility, sometimes described as VAIDS, to be more likely. In addition, “protection from severe disease” also did not prove as durable. More on this later.

That said, I feel that I must present that interesting theory. It will stimulate my readers’ intellect and Mark L likely asked the right questions. It explains that Covid vaccines create a tolerance to spike protein, and because of it, the vaccinated do not have severe illness, but also cannot clear the virus and cannot acquire immunity. (the bigger question, of course, is whether the boosted can acquire immunity to anything else besides Covid. Nobody answered that or even asked.) Again, please consider the piece below critically, but appreciate the originality of Mark L’s thought from Sep 2021.

The text below was NOT written by me.

mRNA Vaccines Elicit Immune Tolerance to Spike Protein

Date: 2021-09-07 05:00 pm (UTC)

From: (Anonymous)

Something strange is clearly going on with regard to the vaccines, aside from the high risk of adverse effects. Despite evidence that they provide protection against symptomatic infection and severe illness, many countries with the highest vaccination rates have the highest illness and hospitalization rates, and the current wave of infection is both much stronger than would be expected in the northern hemisphere summer and also failing to drop off rapidly after a peak as occurred with past waves and the first Delta wave in India. In Israel, where a booster campaign is well underway, positive cases continued to rise even as hospitalizations leveled off, and the case rate is now among the highest of any country on Earth.


Over the past few days I have developed a hypothesis that could help to explain:

·   High disease prevalence in regions with high uptake of genetic vaccines.

·   Increasing disease prevalence following widespread booster vaccination in Israel.

·   High ratios of unvaccinated to vaccinated hospital patients.

·   Much better vaccine protection against severe illness than against infection.

·   Maintained vaccine protection against severe illness over time despite waning immunity.

·   Inferior vaccine protection against infection compared to natural immunity, despite comparable levels of neutralizing antibodies and T/B-cell activation.

·   Higher rates of asymptomatic infection among vaccinated people despite limited testing.

·   Political refusal to test asymptomatic vaccinated people for infection under most circumstances.


The hypothesis is that genetic vaccines are inducing partial immune tolerance to spike protein, likely through a regulatory T-cell response. If any commenters know immunologists or vaccinologists, I would be very interested to hear their thoughts with regard to this idea.

Tolerance is the collective term for a variety of mechanisms used by the human immune system to prevent autoimmunity. Primary tolerance occurs during immune cell development in the bone marrow, and acts to weed out developing immune cells that generate autoreactive antibodies or other autoimmune responses. Secondary tolerance, which is the main focus here, acts to mitigate the effects of autoreactive responses that are already in existence. One of the mechanisms of secondary tolerance is the development of regulatory T-cells, which act to tone down immune responses to particular antigens.


Viruses can exploit tolerance in order to evade the immune system, and this notably occurs with HIV. The viral envelope protein is sufficiently similar in form to a human protein (histone H2A) that an effective antibody response is blocked by tolerance mechanisms, and people with certain autoimmune conditions compromising these tolerance mechanisms actually mount a more effective antibody response against HIV. (https://www.sciencedirect.com/science/article/abs/pii/S0952791516301522)


Increasing tolerance to a pathogen can paradoxically decrease severe disease, when severe disease involves an immune overreaction/cytokine storm rather than actual viral tissue damage. Such is the case with most cases of severe Covid-19 that lead to hospitalization and death. (https://pubmed.ncbi.nlm.nih.gov/33391477/) However, this protective effect comes with trade-offs. When coronavirus-family infections were studied in mice, regulatory T-cells prevented severe immunogenic illness but increased the risk of viral persistence and chronic infection. Furthermore, regulatory T-cell activation can non-specifically dampen immune response to other pathogens, leading to increased incidence of secondary infections. (https://www.mdpi.com/1999-4915/4/5/833/htm)

The main biochemical difference between genetic vaccines and conventional vaccines is that the former present protein antigens to the immune system on the surface of human cells, while the latter present antigens on inactivated viruses or other inert injected particles. Furthermore, when genetic vaccines “infect” a large number of muscle cells, or vessel wall cells, or heart cells, causing them to produce spike protein, the immune system creates conflicting signals. The generated antibodies say “kill that foreign object!” while the self-recognition systems say “that thing just showed up on a bunch of our cells, must be OK!” For this reason, we might expect genetic vaccines to be more likely to induce anti-autoimmunity tolerance mechanisms.

Interestingly, there is an mRNA vaccine in development that is specifically designed to induce tolerance as a treatment for autoimmune disease through activation of regulatory T-cells. The Nature paper describing that work curiously includes the following paragraph: “Sahin and colleagues have clearly demonstrated the potential of RNA lipoplex vaccines to deliver a non-inflammatory form of an mRNA vaccine encoding a self antigen to prevent and limit autoimmune disease in mice. It is noteworthy that m1
Ψ-containing mRNA is also used for the COVID-19 mRNA vaccine, indicating that the pro- versus anti-inflammatory nature of m1Ψ mRNA vaccines can be modulated depending on the specific antigen and specific encapsulating lipid formulation. In the case of the BNT162b2 vaccine for COVID-19, the antigen is a foreign protein formulated in an immunostimulatory lipid nanoparticle. In the present study, the antigen is a self protein delivered in a non-immunogenic lipoplex formulation, and an extra mRNA purification step removes any residual immunostimulatory molecules. This method allows antigen presentation in the absence of inflammation and co-stimulation, preferential expansion of pre-existing T(reg) cells, and possibly also their de novo development.” (https://www.nature.com/articles/s41587-021-00880-0)



In other words, they claim that the immune response to an mRNA vaccine can be switched between tolerance and immunity by choosing a self or foreign protein and selecting a pro- or anti-inflammatory lipid formulation for the encapsulation. I highly doubt that it’s that simple, and I strongly suspect that unintentional induction of partial tolerance is a likely side effect of any genetic vaccine.


Conveniently, in the case of Covid-19, it turns out that tolerance is protective against severe disease, and indeed some treatment efforts have focused specifically on enhancing immune tolerance (https://journals.ekb.eg/article_92759.html). However, immune tolerance may also be associated with prolonged virus shedding (https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(20)30273-X/fulltext). If the genetic vaccines do indeed induce partial immune tolerance, that could help to explain their impressive efficacy against the sort of immune overreaction that leads to hospitalization and death, while also explaining their comparative weakness in preventing infection and transmission of the virus. If “long covid” is, as many scientists suspect, partially induced by autoreactive antibodies, then it would also make sense that genetic vaccines could reduce or eliminate those symptoms by inducing tolerance. This could help to explain the phenomenon that vaccination sometimes alleviates long covid, and also reduces the incidence of long covid in breakthrough infections.

This is an eminently testable hypothesis that can be explored by examining regulatory T-cell responses (or other immune tolerance responses) following vaccination. To date, I can find no evidence that anyone has done this, but I would hope that it will happen in the near future, and the results will be illuminating.

Tolerance is not an on/off phenomenon but rather a wide spectrum ranging from the complete immune acceptance of most of our own proteins to the extreme reactogenicity of a serious peanut or bee sting allergy. Tolerance mechanisms can coexist with immunity mechanisms, such that tolerance begins to become apparent as the level of neutralizing antibodies declines. And to be clear, I am not hypothesizing that the genetic Covid-19 vaccines function by virtue of inducing tolerance. It has been well-demonstrated that they induce a strong neutralizing antibody response. I am instead suggesting that they may *also* be inducing partial tolerance, and that this effect may help to explain strong protection against severe (immune overreaction) disease, high rates of illness transmission in high-vax areas, and possibly also significant declines in immunity after 4-6 months despite continuing high antibody levels.


If indeed the genetic Covid-19 vaccines are inducing partial tolerance, we can make certain predictions:

1.    Genetic vaccines will be extremely effective at preventing severe disease, but much less effective in terms of preventing infection. (True)

2.    As vaccine immunity wanes, protection against cytokine-storm-type severe disease will be maintained. (Seems to be true)

3.    As vaccine immunity wanes, vaccinated people will increasingly carry and spread the virus, and population-level viral prevalence will rise in areas with a high uptake of genetic vaccines. (True) Vaccinated people will be more likely to be asymptomatic carriers. (True, https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(21)00460-6/fulltext)

4.    This will lead to a significant wave of illness transmission which will disproportionately affect unvaccinated people (who are not protected against severe disease). (True right now across the US and much of the world)

5.    Booster shots will further increase tolerance, leading to an increased level of disease prevalence across the population. (True in Israel)

6.    As immunity wanes and new antibody-resistant variants emerge, vaccinated people will be more vulnerable to long-term/chronic infection with high viral loads. Due to the protective effects of tolerance this will likely manifest not as typical severe Covid-19 illness (pneumonia, ventilators, cytokine storms, multiorgan failure) but rather as spike protein toxicity. So we should watch for an increase in clotting, strokes, heart attacks, myocarditis, neurological problems, etc. Vaccinated patients dying of these conditions may not be tested for Covid-19 and so likely will not be counted as covid deaths, and the myth of vaccine efficacy may persist based on the original definition of “preventing severe Covid-19 disease” even as we experience a wave of mysterious illness and death. Furthermore, vaccinated people may be more vulnerable to other infections due to regulatory-T-cell mediated general immune suppression. Should ADE develop, with non-neutralizing antibodies facilitating enhanced infection or direct infection of immune cells, tolerance could well lead to further exacerbation. However tolerance could also provide protection against cytokine storm-type reactions and accelerate the evolution of SARS-CoV2 into an endemic human pathogen, so the long-term effect of tolerance is uncertain.

7.    Contrary to the shrill claims of the fearful, vaccinated people will present a much greater danger than unvaccinated people in terms of asymptomatic transmission and evolution of new variants.

8.    There are likely to be significant differences between the vaccines. In particular, the two-shot series would be expected to induce greater tolerance, and possibly also greater tolerance will be evident in countries with a shorter interval between the two shots. Countries that utilized inactivated-virus vaccines are probably less likely to see tolerance effects, although they may still encounter ADE or other problems down the road.



This hypothesis presents a scenario of vaccine failure that first appears as success (because tolerance prevents severe disease), that explains the trends currently observed (unexpectedly high illness rates in high-vax areas), and that potentially portends a troubling future without invoking the still-hypothetical ADE.
As with JMG’s original hypothesis, time will tell…

Mark L



UPDATE: One of our own, El Gato, published a VERY prophetic article on Sep 16:

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274 Comments

 


Jennifer

14 hr agoLiked by Igor Chudov

There is graphene oxide in those shots. It is shedding off onto those of us who didn't take the shots. I have been sick for 15 months until recently. I found a doctor who hasn't sold his soul to the CDC. They found graphene oxide in my blood. It had my white blood cells suppressed. I am on a protocol to remove g.o from my blood. It is working!! I would love to talk to someone who can help me get this protocol out to the public so people can get help.

 

 

 

JustANobody

14 hr agoLiked by Igor Chudov

I would reach out to FLCCC. Dr's P.Kory and Paul Marik. They have all kinds of protocols from prevention to v injured. Good Luck.

 

 

 

Kelliann

14 hr agoLiked by Igor Chudov

Tell us more, please.

 

 

Naunie4TrthXpsd

13 hr ago

Ditto thAT!!

Yes, pLease Jennifer, would love to hear more of your story!! Like, how g.o. was found in your blood? Was it a simple blood test? Your symptoms? The protocol?? Share awayyy... ; )

Incredibly intriguing as I too have been experiencing oddities after being around the jab'd - low fever for days, mild sore throat, increased cough, and just general feeling unwell. Actually going to my GP tomorrow for blood work, after a 2wk run of fever, aFter going ouT to dinner for first time since start of pLandemic with out-of-town jab'd family, jab'd siblings, and gathering following day as well. Been on coNvid prophylactic protocol, even did 5 day course Ivermectin/early trtmnt protocol.!.

I feel like I sound absolutely crAzy relating my symptoms to the jab'd, but how many times can coincidence happen, ya know!?!

I aM immunocompromised (MS), don't have regular human contact, still haven't yet reunited with my production plant working jab'd husband - just me, my two crAzy Bengal cats, and all you like minded folks and communities that help keep me sane. Sighhh...pardon my novel. : ]

Also - IncrEdible piece Igor!!! Endless thanks to you!!!

 

 

 

Jennifer

11 hr ago

It started after I was exposed to 63 vaccinated elderly residents in a nursing home. It started with headaches, which I rarely get. I began having extra menstrual cycles. I found a knot in my breast. I made an appointment with my family doctor. He did blood work that only revealed high estrogen levels. The knot ended up being a cyst. This doctor told me he suspected I was experiencing V shedding. So I began to read everything I could find. Some doctors call it transferring. I had to quit my job. For the next 14 months I had 2 and 3 full week periods every month. 2 months ago my BP dropped down to 90/50. I have a friend who works with AFLDS citizen corp group. He told me the name of a clinic that treats "hundreds" of women who have the same symptoms. As I waited for my appointment I continued to read. I found an article that suggested several supplements. Quercetin. D3, zinc, NAC, milk thistle, astaxanthin, ivermectin and HCQ. So I began those. The doctor added more. My blood was beginning to coagulate so I'm taking nattokinase for that. Ovex to stop the bleeding. AC Carbamide, glutathione and chelation therapy.

I have now gone 22 days without bleeding. I have my energy back. No more feeling heavy and weighted down. The last 3 mornings I have woke up without feeling hungover.

I am also being extra careful not to touch or get in anyones breathing space.

 

 

 

Jennifer

11 hr ago

I specifically asked them to check my blood for graphene oxide. I have read in several places and heard a few doctors say they believe it is g.o. So I asked them to check. That was the only toxin found in my blood work.

12 replies

 

 

Adria Pecora

Writes Parking Lot8 hr ago

I am sorry that you went through that and glad that you are feeling better. Thank you for sharing your experience and learning.

 

 

 

midama

13 hr ago

Shedding is not a myth. You do not sound crazy at all.

 

 

 

Naunie4TrthXpsd

10 hr ago

ThAnk you for that!!

 

 

 

JamesDuff

12 hr ago

Jennifer I did not get vaxxed.

I am soon to drive medical patients

To their appointments, my wife is

Doing this too. I suspect most people

Will have been vaxxed …

I’d like to know about prevention

Or any practical things we can do

If you have any words of advice

Thanks.

 

 

 

Jennifer

11 hr ago

Read my reply above. The best advice I can give, other than the regimen I am on, is to don't touch them. I would crack their window if riding with them. I am now getting calls from men who are also bleeding.

 

 

 

midama

8 hr ago

Okay, I’m just gonna go ahead and ask... bleeding from where?

 

 

 

JamesDuff

7 hr ago

Thanks for asking that question.

1 reply

 

 

Jennifer

1 hr ago

Vaginal bleeding. I have an uncle who started bleeding out of his penis after his wife took the booster shot. I'm reading stories of people getting nose bleeds, flu like symptoms, rashes....

Before I left the nursing home, 80-100 year old women started having periods! I reported every incident to the nurses. Not a single one of them questioned or put two and two together. They simply called the doc and asked him to put the residents on hormones.


 

 

Naunie4TrthXpsd

8 hr ago

HOly heck!! That's insane. Thank goodness for you getting the good medical attention you did!!

 

 

 

JamesDuff

10 hr ago

Really bleeding? I will use widow.

Was suggested using silver mask

Ivermectin and other vitamins taking.

 

 

 

Jennifer

1 hr ago

Personally, I think keeping our immune system as strong as possible is our best defense. I am using ivermectin daily, so are my family members.

1 reply

 

 

Bibi

12 min ago

Hi Jennifer

glad to hear you are able to remove g.p from your blood. If you do not mind, I am curious about the protocol you are on. I noticed extreme tiredness and ichiness in my nose when I socialise with vaccinated people. I am unvaccinated and never had covid but I am suspecting that I might "have" it without actually having symptoms hence curiousity about protocol.

 

 

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Weihan Xing

14 hr agoLiked by Igor Chudov

Numerous studies have now clearly documented a noticeably dampened T-cell 8+/4+ response to other viruses and cancer cells, in part because the pseudouridine substitution in the mRNA vaccine negatively affects the toll-like receptors 3, 7, and 8. In the long-term, this is especially worrying with respect to cancer, and pathologists in several independent labs in a number of countries are witnessing an explosion in unusual cancers among the vaccinated. GPs, too, are expressing concern over unusual and far more frequent types of cancer, even in young people, than they had ever witnessed before in their careers. One doctor in Florida noted that he had seen 5 younger patients this year alone with an unusual type of kidney cancer. He had seen only one such case in the prior years he had been practicing. German pathologists has used the terms "turbo cancer" to describe the sudden re-emergence of particularly aggressive forms of cancer in vaccinated patients that had been successfully treated and were in remission prior to vaccination.

The same types of susceptibility in the vaccinated are now being documented for Epstein-Barr, Herpes simplex, Herpes zoster, and several other viruses.

24 replies by Igor Chudov and others

272 more comments…

 

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