March 30 2022
Poor virus-neutralizing capacity in highly C-19 vaccinated populations could soon lead to a fulminant spread of Sars-CoV-2 super variants that are highly infectious and highly virulent in vaccinees while being fully resistant to all existing and future spike-based C- 19 vaccines
Key message
I SERIOUSLY expect that a series of new highly
virulent and highly infectious SARS-CoV-2 (SC-2) variants will now rapidly and
independently emerge in highly vaccinated countries all over the world and that
they will soon spread at high pace. I expect the current pattern of repetitive
infections and relatively mild disease in vaccinees to soon aggravate and be
replaced by severe disease and death. Unfortunately, there is no way vaccinees
can rely on assistance from their innate immune system to protect against
coronaviruses1 as their relevant2 innate IgM antibodies are increasingly being
outcompeted by infection-enhancing vaccinal Abs, which are continuously
recalled due to the circulation of highly infectious Omicron variants. In
contrast, Omicron’s high infectiousness would enable the nonvaccinated to train
their innate immune defense against SC-2 while the infectious and pathogenic
capacity of the new SC-2 variants would be debilitated in the non-vaccinated for
lack of infectionenhancing Abs in their blood. Unless we immediately implement
large scale antiviral prophylaxis campaigns in highly vaccinated countries,
there shall be no doubt that the pandemic will end by taking a huge toll on
human lives.
../..
Why this
call?
I know this
is a bad time to share my deep concerns about the future evolution of this
pandemic. I know the world is currently getting more than enough of very
concerning news; in addition, scary predictions about the future evolution of
this pandemic are never welcome. The only reason why I nevertheless continue
to express my concerns is that I cannot refrain from urging national and
international public health agencies to immediately engage their populations in
large scale antiviral chemoprophylactic campaigns, especially in highly
vaccinated countries. Given the high infectivity rate that characterizes
the spread of Omicron, the rather ‘mild’ course of infections we are currently
witnessing cannot be considered the endgame prelude of this pandemic. Even if
the mass vaccination program were immediately halted, a spectacular and
immediate reduction of viral infection rates in highly vaccinated populations
would be required to prevent these populations from further exerting spike
(S)-directed immune pressure on Omicron. Based on the analysis of molecular
epidemiologists, there can be no doubt that convergent evolution of SC-2
towards protection of its life cycle from host immune attacks will continue for
as long as these attacks will threaten the life cycle of the virus but not in
ways that can fully prevent its replication and transmission. Because of strong
selective immune pressure on viral infectiousness, the virus has already turned
to expansion in prevalence of highly infectious variants as a mechanism to
ensure its survival and to escape new immune attacks. As will be explained
below, the evolution of SC-2 towards more virulent circulating variants
directly results from the combination of its resistance to potentially
neutralizing vaccinal Abs and the high level of infectiousness it achieves in
highly vaccinated populations. It is, therefore, paramount that we stop mass
vaccination and immediately reduce the infection rate in the population.
Small
Extract from the official document on the author’s website: https://uploads-ssl.webflow.com/616004c52e87ed08692f5692/6244c3b09ad5701f3ec17765_GVB_s+analysis+of+C-19+evolutionary+dynamics.pdf
Author: G.
Vanden Bossche, DVM, PhD - March 2022
